AI-Powered Agentic System for
Dementia Risk Assesement

Transform clinical decision-making with our interactive agentic AI system.

Paper Code
Impact & Scale

Unprecedented Scale & Accuracy

Evaluating CEREBRA across millions of real-world patient records to deliver state-of-the-art clinical performance.

3M+
Patients
Real-world elderly population analyzed across multiple U.S. healthcare systems.
369M
EHR Records
Massive longitudinal health data integrated across structured records, clinical notes, and imaging.
100K+
High-Fidelity Cohort
Patients with complete multimodal records enabling rigorous benchmarking.
Agents
Multimodal AI
Specialized agents collaborate across EHR, clinical notes, and 3D medical imaging (MRI/OCT).
+17.5%
Clinician Accuracy
CEREBRA significantly improves neurologists’ dementia risk assessment.
0.86
AUROC Dementia Diagnosis
Superior diagnostic performance across multiple hospital systems.
0.80
AUROC 3-Year Risk Prediction
Accurate early prediction of dementia years before clinical diagnosis.
0.81
C-Index Survival Modeling
Strong concordance in time-to-dementia prediction compared with GPT-4o and GPT-5.
Methodology

The CEREBRA Architecture

An interactive, evidence-based AI system that organizes clinical reasoning through coordinated agents to retrieve, analyze, and synthesize information across complex data modalities.

CEREBRA Multimodal Agentic Pipeline Diagram

1. Dynamic Retrieval

Given a clinician's query via the dashboard, the Data Agent automatically identifies and retrieves the relevant temporal windows and modalities from the patient's fragmented health record.

2. Orchestration

A central Super Agent decomposes the diagnostic task into specific goals and assigns them to dedicated, modality-specific reasoning agents.

3. Modality Analysis

EHR, Note, and Image Agents independently process data, validate models, and produce intermediate probability estimates backed by structured evidence.

4. Multi-Agent Synthesis

The Super Agent aggregates these outputs. Clinicians interact with a transparent dashboard highlighting exact clinical snippets and visual evidence underlying the final analysis.

Task

Research Focus

Early Risk Prediction

By analyzing longitudinal health data, CEREBRA achieves highly accurate early prediction of dementia years before clinical onset. Our models are trained on real-world populations to ensure generalizability and reliability over time.

Through robust survival modeling, we are able to provide clinicians with strong concordance in time-to-dementia predictions, outperforming standard baseline models.

Dementia Diagnosis

CEREBRA acts as an expert clinical assistant, analyzing complex patient profiles to assist in accurate and timely dementia diagnosis.

In rigorous validation across multiple hospital systems, the agent demonstrated state-of-the-art diagnostic performance. When used alongside neurologists, CEREBRA significantly elevates the accuracy of clinical risk assessments.

Multimodal Fusion & Missing-Modality Robustness

Healthcare data is notoriously messy and incomplete. CEREBRA utilizes an advanced multimodal fusion architecture that gracefully handles missing data types without failing.

Whether evaluating a complete profile with 3D medical imaging (MRI/OCT) alongside EHR, or functioning purely on sparse structured clinical notes, the agent adapts and maintains robust predictive performance.

Resilient to missing clinical data streams

Refinement through Feedback & Interpretable Logic

Trust is paramount in clinical AI. CEREBRA features specialized agents that not only collaborate to form an assessment but explicitly expose their underlying reasoning.

Through an interactive feedback loop, clinicians can interrogate the agent's logic. The interface allows users to review the exact evidence extracted from clinical notes and imaging markers that led to the final assessment, fostering a collaborative Human-AI diagnostic process.

Fully interpretable agentic logic
Benchmarks

Rigorously Validated, Superior Performance

Clinical Performance

Comparison across diagnosis and longitudinal risk estimation tasks

Diagnosis +16.1%
AUROC
CEREBRA86.2
GPT-4o70.1
GPT-568.5
MedGemma54.8
3-Year Risk Estimation +12.5%
AUROC
CEREBRA80.1
GPT-567.6
GPT-4o66.0
MedGemma55.8
Progression Prediction +18.8%
C-Index
CEREBRA81.2
GPT-4o62.4
GPT-559.1
MedGemma51.5
Platform Demo

Interactive Dashboard

CEREBRA extends dementia risk modeling beyond static predictions toward an interactive decision-support paradigm. Our unified dashboard unifies heterogeneous data for informed, efficient, and transparent clinical assessment.

The dashboard presents overall dementia risk trajectories alongside modality-specific risk factors. For each modality, CEREBRA exposes representative features and clinical snippets that support the various medical tasks, enabling direct inspection of the evidence underlying the model's conclusions.

CEREBRA Interactive Clinical Reasoning Dashboard Screenshot
The Minds Behind CEREBRA

The Team

A multidisciplinary group of AI researchers, software engineers, and clinical specialists dedicated to transforming cognitive care.

AI & Engineering Group
Clinical Group